A few hundred years have passed since human beings settled their lives in the Universe. Humans carried out the Animalman Project to control the population of human beings and animals. They thought that with the execution of the project, human beings and animalmen could help each other to coexist peacefully. However, after the population of animalmen surpassed the population of human beings, an anti-human gang called the Zooligans emerged and they began fighting against humans. The leader of the Zooligans was Buffer-Kong, a cross-animalman that was created by humans! Humans felt that the emergence of the Zooligans was a crisis of the Universe, so they consulted with other animalmen who wished to coexist with humans peacefully. They both agreed to establish Cosmo Keepers to fight against the Zooligans and bring back peace to the universe. The future was in their hands.

- From the game's manual

Clear the stages and defeat the Zooligan bosses! Some stages are simply go from one end to the other, while others require you to race a timer or ride a vehicle on a track for keys to stop a bomb. Blender has moves to help him navigate stages, but will sometimes require the use of certain Mini Bros. to make it to the end. You'll come across bones (currency), hot dogs (health), and 1-ups in stages. There will be times where you have to throw bombs onto switches in out of reach areas like the background.

Extraterrestrial beings, each with their own abilities, that can join forces with Blender during most stages. In the Mini Bros. room, you can play records you have purchased in the Shop for them. Some records can cause them to evolve! You can switch out your Mini Bros. during a stage if you come across a blue and yellow swirl panel.

This Mini Bros. is with Blender from the get-go. He enhances Blender's Spin Attack (Press B button). He likes reggae music.

Press the R button and Blender can ride atop him on water. He likes classical music.

She lights up any dark room automatically. She likes reggae music.

Press the R button and he'll create a barrier that protects against one hit per charge-up. He likes rock music.

In the Mini Game Room at Cosmo Heaven, you can play the three multiplayer mini games by yourself. You can earn crystals and collecting 50 of them will increase Blender's life value to the maximum.

Cosmoride Race

Race on a vehicle around a track. A button accelerates and B button brakes. Hitting walls decreases your speed.

Ear Glide Race

Fall to the goal safely! Use Ear Glide with the B button to slow your fall and avoid the mines. If you hit anything, you're disqualified.

Flag Race

Avoid obstacles while running towards the flag goal. Use A button to jump over the mines.